Oral Capsules
Low-Dose Naltrexone
Compounded low-dose naltrexone (LDN) to support immune balance, inflammation modulation, and well-being.
- Compounded ultra-low dose of naltrexone (1.5–4.5 mg)
- Used in functional, autoimmune, and metabolic medicine protocols
- Modulates immune response and inflammation pathways
- Three capsule strengths: 1.5 mg, 3.0 mg, and 4.5 mg
About the ingredient
Naltrexone (Low Dose)
A pure opioid receptor antagonist compounded at a low dose; the brief receptor blockade is thought to trigger a rebound rise in endogenous endorphins and enkephalins.
Low-Dose Naltrexone (LDN) is a compounded formulation of the opioid receptor antagonist Naltrexone, administered at a fraction of its standard dose to modulate immune function, reduce inflammation, and improve cellular repair.
At low doses (typically 1.5–4.5 mg), Naltrexone temporarily blocks opioid receptors, triggering a rebound increase in the body's production of endorphins and enkephalins. These natural peptides help regulate immune response, reduce chronic inflammation, and improve mood and pain tolerance.
LDN is widely used in functional, autoimmune, and metabolic medicine protocols to support overall wellness, immune balance, and neurological health.
Endorphin rebound
Transient receptor blockade at low doses appears to upregulate endogenous opioid production, which may influence immune signaling.
Immune modulation
Often used in functional and integrative protocols for autoimmune balance and chronic inflammation.
Bedtime dosing
Typically taken nightly. Avoid late-day dosing if it disrupts sleep — your provider can adjust timing.
How to take
A consistent routine matters.
Follow the specific directions from your healthcare provider. These steps are a general reference for oral capsules administration.
- 1
Take one capsule (1.5 mg) by mouth nightly before bed, then titrate per your provider's instructions. Avoid late-day dosing to prevent insomnia.
- 2
Take at the same time each day to maintain steady levels.
- 3
Swallow whole with a full glass of water; do not crush or chew unless directed.
- 4
If you miss a dose, take it as soon as you remember unless it's close to the next scheduled dose — never double up.
- 5
Store at room temperature, away from heat, moisture, and direct sunlight.
Product Details
Available formulations
| Strength | Form | Quantity |
|---|---|---|
| 1.5 mg | Capsules | As prescribed |
| 3.0 mg | Capsules | As prescribed |
| 4.5 mg | Capsules | As prescribed |
Typical dosage & titration
Recommended titration schedule
Reference schedule only — your provider may adjust the timing or dose based on your individual response and lab work.
| Weeks | MG | SIG / Directions |
|---|---|---|
| 1–2 | 1.5 mg daily | Take one capsule (1.5 mg) by mouth nightly before bed. |
| 3–4 | 3.0 mg daily | Increase to one capsule (3 mg) nightly as tolerated. |
| 5+ | 4.5 mg daily | Maintain one capsule (4.5 mg) nightly before bed, or as directed by provider. |
Avoid late-day dosing to prevent insomnia.
FAQ
Frequently asked questions
Provider workflow
Ready to prescribe Low-Dose Naltrexone?
Submit a prescription through the Logos RX provider portal, or reach out to our pharmacy team for formulary, dosing, or patient-onboarding questions.
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