Oral Tablets
Metformin
First-line oral therapy that improves insulin sensitivity and supports metabolic health.
- First-line therapy for insulin resistance
- Reduces hepatic glucose production
- Often paired with GLP-1 therapy for synergistic metabolic effect
- Available in 500 mg, 850 mg, and 1,000 mg tablets
About the ingredient
Metformin Hydrochloride
A biguanide that decreases hepatic gluconeogenesis and increases peripheral glucose uptake, improving insulin sensitivity.
Metformin Hydrochloride is a first-line oral medication used to improve insulin sensitivity and support metabolic health. Originally developed for the management of type 2 diabetes, Metformin is now also recognized for its broader benefits in weight control, cardiovascular support, and longevity optimization.
Metformin works by reducing hepatic glucose production, increasing peripheral glucose uptake, and enhancing insulin sensitivity — helping regulate blood sugar levels and support steady metabolic function. It is frequently prescribed as part of comprehensive metabolic and weight optimization protocols, including those involving GLP-1 receptor agonists.
Lowers hepatic glucose
Metformin's primary mechanism is suppression of liver gluconeogenesis, the largest contributor to fasting hyperglycemia.
Insulin sensitizer
Improves peripheral glucose uptake without forcing additional insulin release — a low hypoglycemia risk profile when used as monotherapy.
Longevity research interest
Ongoing studies (e.g. TAME) are evaluating metformin's potential role in cellular aging and cardiometabolic resilience.
How to take
A consistent routine matters.
Follow the specific directions from your healthcare provider. These steps are a general reference for oral tablets administration.
- 1
Take one tablet (500 mg) by mouth twice daily with morning and evening meals.
- 2
Take at the same time each day to maintain steady levels.
- 3
Swallow whole with a full glass of water; do not crush or chew unless directed.
- 4
If you miss a dose, take it as soon as you remember unless it's close to the next scheduled dose — never double up.
- 5
Store at room temperature, away from heat, moisture, and direct sunlight.
Product Details
Available formulations
| Strength | Form | Quantity |
|---|---|---|
| 500 mg | Tablets | As prescribed |
| 850 mg | Tablets | As prescribed |
| 1,000 mg | Tablets | As prescribed |
Typical dosage & titration
Recommended titration schedule
Reference schedule only — your provider may adjust the timing or dose based on your individual response and lab work.
| Weeks | MG | SIG / Directions |
|---|---|---|
| 1–4 | 500 mg daily | Take one tablet (500 mg) by mouth twice daily with morning and evening meals. |
| 5+ | 1,000 mg daily | Maintain one tablet (1,000 mg) by mouth twice daily, or as directed by your provider. |
FAQ
Frequently asked questions
Provider workflow
Ready to prescribe Metformin?
Submit a prescription through the Logos RX provider portal, or reach out to our pharmacy team for formulary, dosing, or patient-onboarding questions.
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