Injectable
PregnylHuman Chorionic Gonadotropin
FDA-approved Human Chorionic Gonadotropin (hCG) used to preserve testicular function and fertility during testosterone therapy.
- Commercially available, FDA-approved hCG
- Mimics luteinizing hormone (LH) to stimulate endogenous testosterone production
- Helps preserve testicular volume and fertility on TRT
- Supplied as a lyophilized powder with mixing kit included
About the ingredient
Chorionic Gonadotropin (hCG)
A glycoprotein hormone that binds to LH receptors on testicular Leydig cells, stimulating endogenous testosterone synthesis.
Pregnyl (Human Chorionic Gonadotropin, or hCG) is a biologically active polypeptide hormone that mimics luteinizing hormone (LH), stimulating the testes to produce testosterone and maintain fertility. In men undergoing testosterone replacement therapy, hCG helps preserve testicular volume, sustain natural testosterone production, and prevent infertility from gonadotropin suppression.
This formulation of Pregnyl is a commercially available, FDA-approved product that is reconstituted with bacteriostatic water for subcutaneous or intramuscular use. It is commonly prescribed as part of a comprehensive hormone optimization protocol.
LH-mimetic action
hCG shares the same receptor as luteinizing hormone, directly stimulating the testes to produce testosterone — bypassing the suppression that exogenous TRT causes upstream.
Fertility-supportive
Maintains spermatogenesis and testicular volume on TRT, a critical consideration for patients planning future pregnancy.
Commercial FDA-approved product
Pregnyl is dispensed as the brand-name product, not a compounded formulation, and ships with a sterile mixing kit.
How to take
A consistent routine matters.
Follow the specific directions from your healthcare provider. These steps are a general reference for injectable administration.
- 1
Inspect the vial — solution should be clear and free of particles before each use.
- 2
Clean the vial stopper with a fresh alcohol swab and let it air-dry.
- 3
Draw the prescribed dose using an insulin syringe; tap out any air bubbles.
- 4
Inject subcutaneously into the abdomen, thigh, or upper arm, rotating sites each dose.
- 5
Discard the used syringe immediately in an FDA-cleared sharps container.
Product Details
Available formulations
| Vial Total mg | Concentration | mL |
|---|---|---|
| 10,000 IU | 1,000 IU/mL | 10 mL |
Supplied as lyophilized powder with sterile reconstitution kit included.
Typical dosage & titration
Recommended titration schedule
Reference schedule only — your provider may adjust the timing or dose based on your individual response and lab work.
| Weeks | Units | MG | ML | SIG / Directions |
|---|---|---|---|---|
| 1–4 | 40 | 400 IU | 0.40 mL | Inject 40 units (400 IU) subcutaneously three times per week (Mon/Wed/Fri). |
| 5–8 | 40 | 400 IU | 0.40 mL | Continue same dosing schedule to sustain testicular function and testosterone output. |
| 9+ | 40 | 400 IU | 0.40 mL | Maintain dose or adjust per provider based on labs and clinical response. |
FAQ
Frequently asked questions
Provider workflow
Ready to prescribe Pregnyl?
Submit a prescription through the Logos RX provider portal, or reach out to our pharmacy team for formulary, dosing, or patient-onboarding questions.
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